Stem Cell–derived Exosome Hair Restoration in Tokyo, Japan

“My hair is starting to thin a little.”

That concern is something people around the world can relate to. Regardless of age or gender, the moment thinning or hair loss becomes noticeable, many feel a sense of anxiety—“What if I can never get back to how it used to be?”

Over the years, various approaches such as hair growth tonics, specialized shampoos, and even hair transplant surgery have been tried. Yet, these methods have shown clear limitations when it comes to achieving true, lasting improvement.

This is why growing attention is now being given to regenerative medicine using stem cell–derived exosomes, known as Stem Cell Hair Treatment. By working directly at the cellular level on hair follicles, this therapy offers the potential for natural and sustained results that conventional methods could not deliver.

In this article, we will take a closer look at how hair loss impacts daily life, explain the science behind this cutting-edge treatment, and introduce the safe and reliable therapy offered at Setagaya Internal Medicine Clinic.

The Harsh Reality of
Thinning Hair and Hair Loss Worldwide

Thinning hair and hair loss are serious challenges faced by millions of people, regardless of gender.

In Japan alone, it is estimated that around 12 million people struggle with hair loss. On average, men begin experiencing thinning hair at age 38.6, while for women it begins at 42.1.（ AGA SkinRecruit ）

The causes are varied, with genetic factors and age-related changes certainly playing a role, but stress, lack of sleep, and poor nutritional balance—pressures particularly common in modern society—are also significant contributors.

Because hair loss directly affects one’s appearance, many people suffer from the psychological burden of worrying about “how others see them.” Until now, the most common solutions have been relatively simple measures such as hair growth tonics and shampoos.

However, the effects of these treatments have been temporary at best, with clear limitations when it comes to achieving lasting, fundamental improvement.

This is why innovative regenerative medical treatments are now drawing attention. Hair loss should not be seen as merely a cosmetic issue, but as a critical concern that significantly impacts overall quality of life. Recognizing this is the first step toward finding a true solution.

Not Just Men—Hair Loss Is Increasing Among Women Too

For a long time, thinning hair was regarded as a problem unique to men.

However, in recent years, the rise in hair thinning and hair loss among women has become increasingly evident. Studies show that around 40% of women over the age of 20 experience some form of hair thinning.

Factors unique to women—such as hormonal fluctuations, pregnancy and childbirth, and menopause—are deeply connected to hair health and play a significant role in this growing concern.（Ams-smileAGA Hair Clinic）For women, losing hair volume often makes them appear older than their actual age.

In fact, among women struggling with thinning hair, 52.1% cite stress and 44.4% point to hormonal changes as the main causes. As beauty awareness continues to rise, more women now see maintaining healthy hair as an essential part of preserving their sense of identity and individuality.

In other words, hair loss is no longer just a men’s issue—it has become a serious concern for both men and women alike. People across all age groups are urgently seeking effective solutions.

The Reality That Stress Is Damaging Scalp Health

Stress from work, family, and human relationships has a profound impact on the autonomic nervous system and hormonal balance.

As a result, blood circulation in the scalp deteriorates, sebum secretion becomes unbalanced, and the function of the hair follicles significantly declines.

For women in particular, increased exposure to stressful environments through greater participation in the workforce has contributed to the rise in hair thinning. Prolonged overwork and irregular lifestyles disrupt the hair growth cycle, with increased hair shedding being one of the clearest signs.

Moreover, stress often triggers broader lifestyle disruptions, such as poor diet and lack of sleep. These secondary factors further amplify the risk of thinning hair, creating a vicious cycle that is difficult to escape.

 The Limits of Traditional Treatments

Hair growth tonics and shampoos can help slow the progression of hair loss temporarily.

However, when the hair follicles themselves have lost functionality, it is difficult to expect meaningful results. Hair transplantation, on the other hand, offers faster results but comes with surgical risks, high costs, and the possibility of an unnatural appearance.

In short, most conventional treatments focus on “maintaining existing hair” rather than truly “regenerating new hair.”

This is why there is a growing demand for treatments that work at the cellular level to restore and regenerate the hair follicles themselves.

Four Major Drawbacks of Ignoring Hair Loss
in Daily and Social Life

Losing hair is not just a matter of appearance.

It can have a profound impact on a person’s psychology and social life. The feeling of “losing one’s youth” often makes people reluctant to even look in the mirror, leading to lower self-esteem.

This psychological burden can spill over into personal relationships and confidence at work, ultimately lowering the overall quality of life. What’s more, thinning hair rarely improves on its own.

In fact, if left untreated, it tends to worsen over time.

Here are four major disadvantages of ignoring hair loss: 

Lower Self-Esteem and Psychological Stress

Hair is directly tied to perceptions of youthfulness and appearance, strongly influencing self-image.

Thinning hair often creates the impression of looking “older” or “less clean-cut,” and individuals become highly sensitive to how others perceive them. Psychologically, changes in appearance are linked to reduced self-esteem and an increased risk of depression or social withdrawal.

In fact, a survey by the American Academy of Dermatology (2020) reported that about 40% of men with hair loss experienced a “loss of social confidence.”

Impact on Relationships and Romance

First impressions are crucial in human relationships. In dating and marriage prospects especially, appearance directly affects attraction and interest.

A social psychology study in Germany found that men with a full head of hair were more likely to be perceived as “healthy” and “socially dominant” compared to balding men (Psychology, Health & Medicine, 2019).

This isn’t just a matter of personal preference—evolutionary psychology suggests that abundant hair is subconsciously recognized as a symbol of youth and health.

Loss of Confidence Affecting Career and Social Life

When people begin avoiding public speaking or having their photos taken, their social interactions become limited. Prolonged lack of confidence may also make individuals hesitant about promotions or job changes, which can negatively affect their careers.

Workplace image management is another area where hair loss plays a role. According to a CareerBuilder report, candidates perceived as “youthful and healthy” are often favored in interviews and promotions.

While hair loss does not diminish one’s abilities, impressions such as looking “older” or “less energetic” can work against career advancement.

In Japan, recruitment surveys have also shown that some hiring managers admit to seeing hair loss as a negative factor in first impressions.

Restrictions in Daily Life

Appearance changes are directly tied to self-perception. Hair, in particular, is seen as a “symbol of youth.” As hair loss progresses, fear of being perceived as older grows, gradually undermining motivation in daily activities.

Many people with hair loss start limiting small everyday actions—hesitating to remove a hat at the pool or hot springs, or avoiding public places on windy days.

These limitations extend beyond social settings into hobbies and leisure activities, lowering overall life satisfaction. Feelings of “I used to be more confident and outgoing” may emerge, fueling further psychological distress. Such effects cannot simply be dismissed as “just in the mind.”

Is It Too Late If You Wait? The Dangers of Progressive Hair Loss

Hair loss progresses over time, and in some cases, the hair follicles lose their function completely. Once this happens, recovery with conventional treatments becomes extremely difficult. Early intervention is absolutely critical.

Many people think, “It’s not that bad yet,” and delay treatment—only to find that improvement becomes harder over time. This is the reality. Taking action before the follicles are permanently lost is the key to effective treatment.

A New Answer Born from Regenerative Medicine,
Stem Cell Hair Treatment

In recent years, remarkable advances in regenerative medicine have brought new hope to the field of hair restoration. One of the most promising breakthroughs is the use of stem cell–derived exosomes for treating hair loss.

Exosomes are tiny particles responsible for communication between cells, playing a crucial role in tissue repair and regeneration.

These vesicles, secreted by cells, measure just 50–150 nanometers in size—roughly one ten-thousandth of a millimeter—and are packed with RNA, DNA, and proteins. By harnessing these properties, exosomes can act directly on hair follicles, stimulating new hair growth.

What sets this therapy apart is its potential to achieve fundamental improvements that conventional treatments could never provide. With strong government support, Japan has long been a world leader in regenerative medicine.

This ensures a system where both safety and effectiveness are prioritized—a key reason why global attention is now focused here.

Let’s take a closer look at how exosomes help rejuvenate weakened hair follicles.

How Stem Cell–Derived Exosomes Revitalize Hair Follicles

Exosomes target hair matrix cells and dermal papilla cells, reactivating weakened follicles. They promote the proliferation and activation of dermal papilla cells, which provide vital support for hair growth. This restores the natural hair cycle and creates the right conditions for new hair to grow.

Studies show that exosome therapy can suppress the regression of dermal papilla cells by up to 45%. In other words, it extends the growth phase of the hair cycle, reduces shedding, and promotes longer-lasting growth.

Because this treatment works at the cellular level, it offers more natural results than traditional topical medications or surgical hair transplantation. It represents a groundbreaking step forward in hair restoration.

Moreover, since exosomes serve as carriers of biological information, they can deliver active molecules to follicle cells more efficiently and stably than conventional mesotherapy.

Reducing Scalp Inflammation
and Creating an Ideal Growth Environment

Chronic inflammation and poor circulation are often underlying factors in hair loss. Exosomes have anti-inflammatory properties and support tissue repair. They also promote angiogenesis—the formation of new blood vessels—and studies have confirmed a significant increase in angiogenic factors after treatment.

This dual action helps improve scalp health and provides an ideal environment for hair follicles to thrive.

Rather than simply “adding hair,” exosome therapy works to enrich the very foundation where hair grows. It can be compared to cultivating fertile soil by restoring the scalp’s natural balance, the hair is able to grow stronger and healthier.

Five Reasons
Why Japan’s Medical Care Is Chosen Worldwide

With strong government support, Japan is advancing eight major research programs using iPS cells to regenerate the retina, heart, platelets, immune cells, and more. These efforts are said to be several years ahead of other leading regions such as Europe, the United States, and China.

So why do patients from overseas travel all the way to Japan specifically for exosome therapy? Here are five key reasons:

A Leading Accumulation of Regenerative Medicine Research

Japan has earned global recognition for its pioneering work in regenerative medicine, especially in iPS cell research.

Nationally supported projects involving the retina, heart, and immune cells have expanded into applications such as hair restoration. The high level of research serves as the foundation for the reliability of clinical treatments.

Strict Quality Control that Meets International Standards

Exosome formulations used in treatment are produced under rigorous quality control, in compliance with the standards set by the International Society for Extracellular Vesicles (ISEV).

In Japan, every step from manufacturing to clinical application is transparently traceable, ensuring safety and reliability. This thoroughness behind the scenes is a unique strength of Japanese medicine.

Physician-Led, Comprehensive Care

At Japanese medical institutions, doctors are directly involved throughout the entire process—from diagnosis to treatment and aftercare.

Should any unexpected reactions occur during therapy, immediate expert evaluation and intervention are available. For international patients, the reassurance of “always having a doctor by your side” is one of the strongest reasons for choosing Japan.

A Culture That Prioritizes Ethics and Safety

Japan has established robust legal frameworks such as the Act on the Safety of Regenerative Medicine.

All treatments must undergo ethical review and safety verification before being offered to patients. The principle of “delivering only what has been confirmed to be safe” reflects the very essence of Japan’s medical culture.

A Unique Patient Experience Combining Medicine and Hospitality

Japanese medical care is not only backed by science but also characterized by attentive patient-centered service.

From reception to treatment and aftercare, the approach is meticulous and compassionate. For patients traveling from abroad, this blend of hospitality and medical excellence ensures a truly reassuring treatment experience.

Before and After of Exosome Treatment
at Setagaya Internal Medicine Clinic

＼ Growth Factors × Medical Microneedling ／
Setagaya Internal Medicine’s Safe and
Reliable Exosome Scalp Treatment Program

Since its opening in 2021, Setagaya Internal Medicine & Diabetes Comprehensive Clinic has been continuously offering treatments using stem cell–derived exosomes, including nasal sprays and eye drops.

In recent years, many exosome-containing nasal and eye drops have been marketed online and through social media advertisements. As a result, our clinic has received numerous inquiries regarding the quality and manufacturing background of these products.

To address these concerns, we would like to outline the key features and precautions of the exosome nasal sprays we provide.

Three Key Features of Our Treatments

Aesthetic medicine can help improve concerns about the skin and hair while restoring self-confidence.

However, many people worry about two common drawbacks: pain during treatment and downtime afterward. In traditional procedures, discomfort, redness, and swelling were often considered unavoidable.

At Setagaya Clinic, we have overcome these challenges by integrating cutting-edge medical devices with the latest knowledge in regenerative medicine.

As a result, we are able to offer advanced, low-pain aesthetic treatments that are now attracting attention from patients around the world.

Strict Manufacturing Standards and Safety to Protect the Quality of Stem Cell Culture Supernatant

The stem cell culture supernatant we use (max NFC / CLASS / EXOPure) is produced under the same rigorous standards as those applied to intravenous infusion therapies. This ensures that even when used as a nasal or eye drop, the same level of quality and safety is maintained.

• No antibiotics, preservatives, or synthetic additives (such as EGF) are ever included.
• Our formulations are produced by specialized culture technicians using a unique “natural culture method,” ensuring a high concentration and stable presence of exosomes.
• All manufacturing takes place in a Ministry of Health, Labour and Welfare–approved domestic CPC (cell processing center) within our affiliated group. Every step of the process is designed to completely remove impurities such as ammonia.

We also place great emphasis on the stem cells used as raw material. Unlike many other facilities, we never use frozen cells. Instead, fresh stem cells from living donors are transferred to culture within 24 hours, preserving their natural freshness and activity to the fullest extent when producing the supernatant.

Why Our Exosome Nasal Spray Is Safe to Use

In today’s market, there are products that are heavily diluted compared to proper medical concentrations, as well as those lacking sufficient evidence of safety. Using such products not only reduces effectiveness but may also pose health risks.

At Setagaya Internal Medicine Clinic, we provide only formulations that meet the same strict quality standards used in regenerative medicine and are proven safe for medical use.

• Each production lot undergoes component analysis and quality verification.
• The culture supernatant, rich in high concentrations of cytokines and exosomes, is carefully processed into nasal and eye drop formulations.
• The concentration is equivalent to that used in intravenous therapy.

Because of these standards, our exosome nasal spray has even been adopted in medical facilities for inpatient rehabilitation of neurological disorders. Patients can use our products with confidence, knowing they are backed by both safety and proven quality.

Thorough Initial Consultation to Understand Your Needs

At Setagaya Internal Medicine, we place great importance on careful listening. During your first consultation, we take the time to understand your scalp condition, past treatment history, lifestyle habits, and personal goals in detail.

For about 13 years, I have been involved in the prevention and treatment of a wide range of internal medicine conditions at university hospitals, community hospitals, home care settings, and as a clinic director in Tokyo. In 2021, I founded Setagaya Internal Medicine Clinic.

From the very beginning, our clinic has actively incorporated treatments using stem cell–derived exosomes as part of our comprehensive medical care.

 

We place great importance on open communication with each patient, carefully tailoring treatment methods and selecting the most appropriate type of exosome to suit individual conditions.

– Director, Setagaya Internal Medicine & Diabetes Comprehensive Clinic

• Board-Certified Diabetes Specialist, Japan Diabetes Society
• Board-Certified Anti-Aging Specialist, Japan Society of Anti-Aging Medicine
• Certified Physician of Internal Medicine, Japanese Society of Internal Medicine
• Certified Industrial Physician, Japan Medical Association
• Certified Food Education Practitioner, Japan Taste Education Association
• Certified Food Coordinator, Japan Food Coordinator Association 

Flexible Treatment Plans Tailored to Each Patient

Treatment frequency and duration are adjusted individually. Depending on the progression of your symptoms and the level of improvement you wish to achieve, we design an optimal plan that balances effectiveness and comfort. Our priority is always to deliver both results and peace of mind.

Treatment Flow

What is Collagen Induction Therapy?

Collagen Induction Therapy, also known as Percutaneous Collagen Induction (CIT / PCI), is a treatment performed with microneedling, where tiny controlled micro-channels are created on the skin’s surface.

These micro-injuries close quickly, leaving no scars, and immediately trigger the body’s natural healing response. As the skin begins to repair itself, fibroblasts are activated, leading to increased production of collagen and elastin. This process results in improved elasticity, firmness, and a natural lifting effect.

Clinical studies have shown that even a single session can increase collagen production by more than 300%, with the effect peaking about 24 hours after treatment. Visible improvements typically appear within 3 to 12 weeks, and maximum results are often observed between 6 to 12 months.

Newly produced collagen can last for over a year, and regular treatments help to extend and enhance these benefits. For this reason, CIT is widely recognized not only for reducing wrinkles and sagging but also for improving overall skin quality through a regenerative approach.

How Many Sessions Are Needed to See Results?

For cosmetic goals such as skin rejuvenation or anti-aging, individual responses can vary. In the case of thinning hair and AGA, the underlying cause is a disrupted hair cycle, so restoring that cycle takes time.

Most patients begin to notice improvements around 3–4 months after treatment starts. The exact number of sessions needed differs by case, but we carefully monitor progress and adjust the plan accordingly.

Typically, patients visit once every 1–2 weeks to once a month, with multiple sessions recommended. The schedule is always customized based on the physician’s diagnosis.

If you are already receiving exosome therapy abroad, please consult with us in advance for safe coordination.

Physician-Supervised Care for Safety and Reliability

Because stem cell–derived exosome therapy is a medical procedure, specialized knowledge and oversight are essential. At Setagaya Internal Medicine, all treatments are supervised by physicians, with strict control over both treatment protocols and the quality of formulations used.

Exosome therapy is generally considered to have minimal side effects and no downtime. Since exosomes are naturally present in the human body, the risks of infections or severe reactions such as anaphylaxis are extremely low.

Cost of Exosome Treatment

The cost of exosome therapy varies depending on the treatment method. For injections, the average price is around ¥50,000 to ¥100,000 per session. Since exosome therapy is generally not covered by insurance, it is offered as self-funded medical care.

For intravenous drips, the cost typically ranges from ¥30,000 to ¥200,000 per session. This variation depends on factors such as the source of the cultured exosomes and the concentration of active components used.

At Setagaya Internal Medicine, we strive to keep treatment as accessible as possible by offering reasonable pricing while maintaining the highest quality of exosome formulations.

For patients considering multiple sessions, we also provide course plans. Full details are explained during the initial consultation.

max NFC Premium 2cc

This is the world’s only human stem cell culture supernatant created by combining all four of these cell types. It represents the forefront of regenerative medicine.

THE CLASS – Umbilical Cord–Derived (2cc)

This product is developed using umbilical cord–derived mesenchymal stem cells, which are among the youngest and most biologically active stem cells available. Their rarity and regenerative potential make them highly valued in advanced regenerative medicine.

EXO PURE – Dental Pulp / Adipose–Derived (2cc)

EXO PURE is an ultra-high-concentration stem cell culture supernatant, available in two types—dental pulp–derived and adipose–derived. Both formulations are distinguished by their exceptionally high cytokine content, making them among the most advanced and potent products currently used in the field of regenerative medicine.

FAQ

Regarding the Use of Unapproved Medical Devices and Products

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